High-grade prostatic intraepithelial neoplasia (HGPIN) incidence has declined after extended prostate needle biopsies. The likelihood of identifying prostate adenocarcinoma in patients with an initial H-PIN diagnoses is not higher, as was supposed to be in earlier studies. Therefore, the need for a rebiopsy in these patients should be reconsidered. The current retrospective study assessed the subsequent likelihood of identifying prostatic adenocarcinoma (PCa) in 41 of 73 patients with an initial diagnosis of ‘‘widespread'' HGPIN defined as HGPIN present in 4 or more biopsy cores. Pca was found in 16/41 patients (39%). Patients