Article - Comment

Fuhrman grading is not appropriate for chromophobe renal cell carcinoma

  • Kutsal Yörükoglu

Bull Urooncol 2007;6(4):37-38

This study assessed the prognostic significance of Fuhrman nuclear grading in chromophobe renal cell carcinomas. Eighty-seven cases of chromophobe renal cell carcinoma were re-analyzed and Fuhrman nuclear grade, focal highest grade of the tumor, and nuclear measurements by image analysis were noted. Six cases were Fuhrman grade 1, 72 cases were grade 2, 8 cases were grade 3, and 1 case was grade 4, whereas focal (single high power field) grading was grade 1 in 1 case, grade 2 in 62 cases, grade 3 in 21 cases, and grade 4 in 3 cases. Follow-up ranged from 1 to 150 months and 8 patients died of tumor-related causes. Only patient age and tumor maximum diameter were found to be significant iricscul puiusgogii. Whole gradings and nuclear image analysis parameters showed no significant association with outcome. Fuhrman grading, nor any of the components are useful as prognostic indicators for chromophobe renal cell carcinomas.