Objective:
In this report, patients, who had testosterone (TE) level data before prostate needle biopsy and who later underwent radical prostatectomy (RP) due to prostate adenocarcinoma, were evaluated. The TE levels were analyzed in patients divided into three groups according to the D’Amico risk classification.
Materials and Methods:
Patients in the low-risk group constituted group 1, those in the intermediate-risk group-group 2 and subjects of the high-risk group were in group 3. Prostate specific antigen and TE levels, biopsy and RP pathological findings and biochemical recurrence rates were evaluated. Then all data were compared between the groups.
Results:
We evaluated 81 patients, whose data on TE level were available. Twenty eight patients were included in Group 1, 45 were in Group 2 and 8 were in Group 3. The mean follow-up time was 37.7 months. Total testosterone (GTE) levels were detected to be lower in Group 3 (p=0.033) than in patients of Group 1 and Group 2. However, pathological stage (p=0.004), Gleason score (p<0.001), tertiary Gleason pattern (p=0.032), tumor volume (p<0.001), surgical margins positivity (p=0.023), lymph node positivity (p=0.01) and biochemical recurrence (p=0.026) rates were found to be higher in Group 3.
Conclusion:
In conclusion, preoperative low TTE levels in patients who underwent RP were found to be associated with high-risk disease according to the D’Amico risk classification.
Keywords: D’Amico risk classification, prostate needle biopsy, testosterone, prostate cancer