ABSTRACT
Coronavirus disease-19 (COVID-19) has been declared as a pandemic by the World Health Organization. The number of cases has increased over time in correlation with the increasing number of testing worldwide. In order to use the available resources for COVID-19 treatment, urological practice has been limited only to emergency procedures and certain uro-oncological surgeries. In this report, we aim to share our recommendations for the daily uro-oncology practice in light of local circumstances in Turkey.
Introduction
The human spread of a novel coronavirus, that is, Severe Acute Respiratory syndrome coronavirus 2, was first reported in Wuhan in December 2019 (1,2). The disease was named coronavirus disease-19 (COVID-19), which is basically the short for “COVID-19” (2).
COVID-19 was declared as a pandemic by the World Health Organization on March 11, 2020, which is the same date on which the first confirmed case in Turkey was announced by the Ministry of Health (2). As in other countries, the number of cases has increased over time in correlation with the increasing number of testing in Turkey as well, and as of April 18, 2020, there were 82,329 confirmed cases in Turkey, ranking eighth after China worldwide.
Like in many countries, the urological practice in Turkey has also been limited only to emergency procedures and major uro-oncological surgeries in order to use the available resources for COVID-19 treatments. Although many sources have recently published the general recommendations for the daily practice in urological oncology, a potential concern is if these recommendations would be applicable to every patient from the different geographical regions of the world (3). While the duration of preventive measures, such as lockdowns or social isolations, remains unpredictable, it is of utmost importance that national organizations share their recommendations for daily practice based on national resources, sociocultural circumstances, and restrictive administrative regulations. In this report, we aim to share our recommendations for the daily uro-oncology practice in light of local circumstances in Turkey.
Urothelial Carcinoma (Bladder and Upper Urinary Tract)
a) Patient presented with hematuria and bladder mass
Cystoscopy and transurethral resection (TUR) can be performed as an outpatient procedure, and if the current conditions of the institution are appropriate, we do not recommend postponing this procedure. The current guidelines recommend a single intravesical instillation of chemotherapy in early postoperative period; however, owing to the potential complications of these intravesical instillations and the limited benefit, it is reasonable not to perform early postoperative instillations during COVID-19 pandemic (4,5).
b) Second TUR in patients with pT1 or high-grade urothelial carcinoma
Residual disease can be found in 51%-58% of the patients, of which, 8%-11% are restaged to muscle-invasive disease after a second TUR (6,7). To achieve better oncological outcomes, namely recurrence-free and progression-free survivals, the optimal duration of the second TUR is between two and six weeks after the initial resection (8). A second resection can be performed as an outpatient procedure, and if the current conditions of the institution are appropriate, we do not recommend postponing this procedure and perform it no longer than six weeks after the initial TUR. If there is a sufficient amount of muscle tissue in the specimen confirmed by pathological evaluation and the surgeon is confident of complete resection of all visible tumors, avoiding a re-TUR is an option during this period.
c) Intravesical BCG in patients with carcinoma in situ, pT1, or high-grade urothelial carcinoma
Intravesical Bacillus Calmette-Guérin (BCG) instillations can be performed as an outpatient procedure, and if the current conditions of the institution are appropriate, we do not recommend postponing this procedure since the risk of progression is high. Although, these instillations might cause serious complications, the potential benefits outweigh these risks.
However, intravesical treatment in low to moderate risk non-muscle invasive bladder cancer (NMIBC) can be postponed during this pandemic.
d) Follow-up of non-muscle invasive urothelial carcinoma of the bladder
Patients with low and intermediate-risk tumors: Postponing follow-up cystoscopies in these patients for up to six months is reasonable during the COVID-19 pandemic.
Patients with high-risk tumors: Postponing follow-up cystoscopies in these patients might be reasonable during the COVID-19 pandemic. However, follow-up with urine cytology and imaging of the urinary tract might be offered as an alternative follow-up approach during this period. Nevertheless, we do not recommend postponing the first follow-up cystoscopy at the third month after the initial diagnosis and intravesical induction BCG treatment.
e) Muscle invasive urothelial carcinoma of the bladder
If the current conditions of the institution are appropriate, we recommend performing radical cystectomy in patients with muscle invasive disease. Delaying radical surgery for more than three months is associated with upstaging and lymph node-positive disease, although there are conflicting reports on the overall survival with respect to the timing of radical cystectomy (within 90 days vs more than 90 days after the diagnosis) (9,10,11,12,13). Also, cystectomy for BCG non-responsive high-risk NMIBC should not be delayed.
Generally, higher volumes of hospital and surgeon are associated with lower levels of peroperative and postoperative complications and better oncological results. Referring patients with muscle-invasive disease to high-volume centers might be reasonable during COVID-19 pandemic.
f) Upper urinary tract urothelial carcinoma
Diagnostic ureterorenoscopy and tumor sampling: Can be performed as an outpatient procedure, and if the current conditions of the institution are appropriate, we do not recommend postponing this procedure. However, with regard to the use of a single intravesical instillation of chemotherapy in early postoperative period, due to the potential complications of these intravesical instillations, it seems reasonable not to perform the early postoperative instillations during COVID-19 pandemic.
Radical nephroureterectomy: If the current conditions of the institution are appropriate, we recommend performing radical surgery in patients with high-risk non-metastatic disease. Delaying radical surgery for more than 90 days is associated with worse disease-specific and progression-free survival (14). The current guidelines recommend a single intravesical instillation of chemotherapy in postoperative period; however, due to the potential complications of these intravesical instillations, it seems reasonable not to perform the early postoperative instillations during COVID-19 pandemic.
Prostate Cancer
a) Screening
It seems reasonable not to perform the routine screening with prostate specific antigen (PSA) and/or with digital rectal examination (DRE) during COVID-19 pandemic (15).
b) Prostate biopsy
If the current conditions of the institution are appropriate, we recommend performing prostate biopsy under local anesthesia in a selected group of patients who are admitted with high PSA levels and/or DRE findings compatible with locally advanced high-risk tumors. In all other clinical scenarios, it seems reasonable not to perform prostate biopsy during COVID-19 pandemic (15).
c) Treatment of local and locally advanced prostate cancer
Postponing follow-up visits, imaging modalities for staging, and treatment alternatives (surgery, radiotherapy, etc) in these patients for up to six months seems reasonable during COVID-19 pandemic (16,17). Even in patients with asymptomatic unfavorable intermediate, high, and very high-risk disease, delaying the surgery for up to six months is not associated with deleterious results. However, we do recommend starting androgen deprivation therapy (ADT) during this waiting period.
d) Treatment of metastatic disease
We recommend starting an ADT during COVID-19 pandemic in patients recently diagnosed with metastatic disease. It seems reasonable not to start with docetaxel chemotherapy during COVID-19 pandemic (18). However, if the current conditions of the institution are appropriate, we recommend offering orchiectomy with local anesthesia. The treatment of 150 mg bicalutamide daily may be an alternative for hormonal therapy.
Patients who are undergoing an ADT might benefit from telemedicine, where they can share their PSA and testosterone results with the physician and decide together whether to pause or to continue with their treatment. Three or six monthly forms of luteinising hormone-releasing hormone agonist should be preferred in order to decrease patients’ exposure to medical facilities. Moreover, as a second-line treatment alternatives, we recommend using enzalutamide, abiraterone, or apalutamide instead of docetaxel chemotherapy during COVID-19 pandemic.
Kidney and Adrenal Tumors
a) Management of clinical stage T1 and T2 kidney tumors
A three-month treatment delay in clinical stage T1 and T2 kidney tumors has no negative effect on survival (16). Therefore, it seems reasonable not to perform partial or radical nephrectomy during COVID-19 pandemic. However, in selective cases with cT1b and cT2 tumors and if the current conditions of the institution are appropriate, surgical approach might be offered as the treatment modality (17).
b) Management of clinical stage T3 and T4 kidney tumors
If the current conditions of the institution are appropriate, we recommend performing radical surgery in patients with clinical stage T3 and T4 kidney tumors. Postponing the treatment in these stages can decrease the survival rates and increase the surgery-related morbidities due to a possible risk of aggressive and progressive tumors in these stages (16,17).
c) Tumor biopsy in kidney tumors
No recommendation on performing tumor biopsy prior to deciding on its postponement has been provided in the guidelines. However, it can be recommended to discuss with the patient on the diagnostic value of the tumor biopsy and the status of the center for this procedure and to determine the necessity of tumor biopsy in this regard. In metastatic patients, biopsy can be planned for tissue diagnosing before planning of systemic treatment.
d) The case of kidney tumor-induced hemorrhage
In case of tumor-related bleeding, an emergency radical nephrectomy can be performed according to the hemodynamic status of the patient, regardless of the tumor stage and metastasis status (18). However, primary efforts for embolization by an interventional radiologist seem reasonable during COVID-19 pandemic.
e) Cytoreductive nephrectomy in patients with metastatic disease
The guidelines recommend delaying surgery in such patients with neoadjuvant therapy and minimizing the risk of patient’s contact, especially those who will be undergoing a surgery (19). Moreover, in the current situation, in metastatic kidney tumors, a direct systemic treatment can be started instead of cytoreductive nephrectomy.
f) Follow-up of patients on systemic therapy
Oral (vascular endothelial growth factor-targeted therapy) treatment options might be preferred instead of intravenous therapy (checkpoint inhibitors). In addition, the use of prophylactic antibiotic and growth factor in patients under systemic therapy can reduce the potential morbidity by minimizing the risks of neutropenia and infection (19).
g) Adrenal tumors
If the current conditions of the institution are appropriate, we recommend performing adrenalectomy in patients who have >6 cm adrenal mass or unfavorable radiological findings for adrenocortical carcinoma (17). In other adrenal tumors, it seems reasonable not to perform partial or radical adrenalectomy and to offer follow-up together with endocrinology clinic during COVID-19 pandemic.
Testicular Cancer
a) Patient with a “suspected” testicular mass
Radical orchiectomy can be performed as an outpatient procedure and patients can usually be discharged within 4 hours after the surgery with oral pain medication. We recommend performing orchiectomy if the present conditions of the institution are convenient to perform surgeries (20).
b) Stage I seminoma
We recommend using the risk-adapted approach. Patients without any risk factors (ie tumor size >4 cm or stromal rete testis invasion) should be managed with surveillance. Additionally, while patients with only one risk factor can also be managed with surveillance according to the SWENOTECA trial results (21), patients with two risk factors should, however, be offered an adjuvant treatment. Considering the possible immunosuppressive effects of the chemotherapy agents, adjuvant radiotherapy to the retroperitoneal area using the irradiation dose of 20 Gy can be offered as a reliable alternative (22).
c) Stage I non-seminoma
We recommend using the risk-adapted approach. While patients without any risk factors (ie lymphovascular invasion) should be managed with surveillance, patients with lymphovascular invasion can be offered an adjuvant treatment with one course of bleomycin, etoposide and cisplatin (23). The potential pulmonary toxicity of bleomycin might be a limitation in the current circumstances.
d) Metastatic germ cell tumors
The potential pulmonary toxicity of bleomycin might be a limitation in the current circumstances. For such patients with poor lung function, Cisplatin - Etoposide - Ifosfamide (PEI) protocol can be offered. In addition, the use of prophylactic growth factor should be offered in all patients with germ cell tumors receiving chemotherapy.
e) Patient with post-chemotherapy residual retroperitoneal mass
Considering the acceptable postoperative length of stay (3 to 6 days), we recommend performing retroperitoneal surgery if the present conditions of the institution are convenient to perform surgeries (24).
Conclusion
This report reflects the temporary recommendations for uro-oncological practice in Turkey during the first three months of the COVID-19 pandemic. It is of utmost importance that national organizations share their recommendations for daily practice based on national resources, sociocultural circumstances, and restrictive administrative regulations in order to interact with other societies during pandemic.