ABSTRACT

The exact definition of high-risk prostate cancer remains controversial. D'Amico defined it as a PSA value >20 ng/ml, biopsy gleason score 8-10 or clinical stage≥T2c. High-risk prostate cancer is potentially lethal disease and accounts for ≤%15 of all new diagnosis. The current role of radical prostatectomy in patients with high-risk prostate cancer remains contraversial. But, there are many substantial results that support the use of radical prostatectomy for patients with high-risk localised prostate cancer in current literature. So, radical prostatectomy must be represented as a primary treatment option for selected high-risk patients and can result in long-term progression-free survival.