ABSTRACT

Most of the bladder tumors are urothelial carcinoma, squamous cell carcinoma and adenocarcinoma. Trophoblastic differentiation of urothelial carcinoma is a rare tumor of the bladder. These tumors secrete Human chorionic gonadotropin (β-HCG) and HPL and they have different immunohistochemical characteristics from placental trophoblastic tumors. These tumors are aggressive tumors with poor prognosis and multiple metastases. Primary treatment method is chemotherapy for these tumors.